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Water-Insoluble Drug Formulation by Ron Liu (2018, Hardcover)
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About this product
Product Identifiers
PublisherTaylor & Francis Group
ISBN-10149872941X
ISBN-139781498729413
eBay Product ID (ePID)15038681063
Product Key Features
Number of Pages736 Pages
Publication NameWater-Insoluble Drug Formulation
LanguageEnglish
Publication Year2018
SubjectChemistry / Clinical, Pharmacy, Chemistry / Physical & Theoretical, Pharmacology, Chemistry / General
FeaturesNew Edition
TypeTextbook
Subject AreaScience, Medical
AuthorRon Liu
FormatHardcover
Dimensions
Item Height1.7 in
Item Weight50.4 Oz
Item Length10.2 in
Item Width7.2 in
Additional Product Features
Edition Number3
Intended AudienceScholarly & Professional
LCCN2017-043052
Dewey Edition23
IllustratedYes
Dewey Decimal615.1
Edition DescriptionNew Edition
Table Of ContentIntroduction. Solubility Theory. Prediction of Solubility. Preformulation Aspects of Insoluble Compounds. Water-Insoluble Drugs and Their Pharmacokinetic Behaviors. Regulatory Aspects of Dissolution for Low Solubility Drug Products. Formulation Strategies and Practice Used for Drug Candidates with Water-Insoluble Properties for Toxicology, Biology, and Pharmacology Studies in Discovery Support. Application of Complexation in Drug Development for Insoluble Compounds. Solubilization Using Cosolvent Approach. Emulsions, Microemulsions, and Lipid-Based Drug Delivery Systems for Drug Solubilization and DeliveryPart I: Parenteral Applications. Emulsions, Microemulsions, and Lipid-Based Drug Delivery Systems for Drug Solubilization and DeliveryPart II: Oral Applications. Micellization and Drug Solubility Enhancement. Polymeric Micelles in Water-Insoluble Drug Delivery. Liposomes in Solubilization. Pharmaceutical Salts. Prodrugs for Improved Solubility in Water. Particle Size Reduction. Development of Solid Dispersion for Poorly Water-Soluble Drugs. Alteration of the Solid State of the Drug Substances: Polymorphs, Solvates, and Amorphous Forms. Pharmaceutical Powder TechnologyICH Q8 and Building the Pyramid of Knowledge. Soft Gelatin Capsules Development. Oral Modified-Release Drug Delivery for Water-Insoluble Drugs. Scalable Manufacturing of Water-Insoluble Drug Products. Index.
SynopsisWater-Insoluble Drug Formulation, Third Edition serves as a comprehensive reference for pharmaceutical scientists in the handling of formulation issues related to water-insoluble drugs., Properties and Formulation: From Theory to Real-World Application Scientists have attributed more than 40 percent of the failures in new drug development to poor biopharmaceutical properties, particularly water insolubility. Issues surrounding water insolubility can postpone or completely derail important new drug development. Even the much-needed reformulation of currently marketed products can be significantly affected by these challenges. More recently it was reported that the percentage increased to 90% for the candidates of new chemical entities in the discovery stage and 75% for compounds under development. In the most comprehensive resource on the topic, this third edition of Water-Insoluble Drug Formulation brings together a distinguished team of experts to provide the scientific background and step-by-step guidance needed to deal with solubility issues in drug development. Twenty-three chapters systematically describe the detailed discussion on solubility theories, solubility prediction models, the aspects of preformulation, biopharmaceutics, pharmacokinetics, regulatory, and discovery support of water-insoluble drugs to various techniques used in developing delivery systems for water-insoluble drugs. This book includes more than 15 water-insoluble drug delivery systems or technologies, illustrated with case studies and featuring oral and parenteral applications. Highlighting the most current information and data available, this seminal volume reflects the significant progress that has been made in nearly all aspects of this field. The aim of this book is to provide a handy reference for pharmaceutical scientists in the handling of formulation issues related to water-insoluble drugs. In addition, this book may be useful to pharmacy and chemistry undergraduate students and pharmaceutical and biopharmaceutical graduate students to enhance their knowledge in the techniques of drug solubilization and dissolution enhancement., A drug molecule has to be water soluble to be readily delivered to the cellular membrane but needs to be hydrophobic to cross the membrane. Delivering drugs in water-insoluble formulation is thus a critical matter in therapeutic drug development. This book serves as a comprehensive reference for pharmaceutical scientists in the handling of formulation issues related to water-insoluble drugs. Reflecting the significant progress and advances since the last edition, this edition revises and updates all of the chapters.
LC Classification NumberRS201.S6W38 2018
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