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Gene Delivery to the Blood-Brain Barrier by Louiza Bohn Thomsen (English) Hardco - Picture 1 of 1

Gene Delivery to the Blood-Brain Barrier by Louiza Bohn Thomsen (Hardcover, 2012)

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Product Information

Drug- and gene delivery to the brain is highly restricted by the vascular barriers of the brain, denoted by the blood-brain barrier (BBB) and the blood-cerebrospinal fluid (CSF) barriers. Among these barriers, BBB is the main limiting factor. It is composed by the brain capillary endothelial cells (BCECs). The BCECs barrier function is supported by astrocytes, pericytes and neurons to form the blood-brain barrier. BCECs are very tightly connected to each other by tight junctions. Apart from the essential substrates needed to nourish the brain, small and/or lipophilic molecules are free to diffuse into the brain. However most pharmacologically active drugs and gene fragments are too large to enter the brain. Various kinds of drug-carriers have been constructed for delivery of large substances to the brain. Such drug-carriers have to be able to successfully carry their cargo through the BCECs and into the brain. For testing the ability of drug-carriers to deliver their cargo into the brain, investigators have constructed different in vitro BBB models, consisting of BCECs that express the main characteristics of the BBB in vivo. In the first part of the thesis the ability of two drug-carriers, pullulanspermine and SPIOs, to mediate transfection of BCECs or transcellular transport through BCECs in vitro was studied.

Product Identifiers

PublisherRiver Publishers

ISBN-139788792982148

eBay Product ID (ePID)191366325

Product Key Features

SubjectBiology

Publication Year2012

Number of Pages108 Pages

Publication NameGene Delivery to the Blood-Brain Barrier

LanguageEnglish

TypeTextbook

AuthorLouiza Bohn Thomsen

FormatHardcover

Dimensions

Item Height234 mm

Item Width156 mm

Additional Product Features

Country/Region of ManufactureDenmark

Title_AuthorLouiza Bohn Thomsen