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Developmental Oncology: Principles and Therapy of Cancers of Children and Young Adults by Alex Kentsis and alejandro Gutierrez (2025, Hardcover)
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About this product
Product Identifiers
PublisherCold Spring Harbor Laboratory Press
ISBN-101621825051
ISBN-139781621825050
eBay Product ID (ePID)27070933678
Product Key Features
Number of Pages300 Pages
Publication NameDevelopmental Oncology: Principles and Therapy of Cancers of Children and Young Adults
LanguageEnglish
Publication Year2025
SubjectImmunology, Life Sciences / Genetics & Genomics, Oncology, Internal Medicine
TypeTextbook
AuthorAlex Kentsis, Alejandro Gutierrez
Subject AreaScience, Medical
FormatHardcover
Dimensions
Item Length10 in
Item Width7 in
Additional Product Features
Intended AudienceScholarly & Professional
LCCN2024-045090
Table Of ContentPrefaceToward a Unified Theory of Why Young People Develop CancerAlex KentsisGenetic Predisposition to Hematologic MalignanciesKayla V. Hamilton, Akiko Shimamura, and Jessica A. PollardNew Paradigms in the Clinical Management of Li-Fraumeni SyndromeCamilla Giovino, Vallijah Subasri, Frank Telfer, and David MalkinDevelopmental Dysregulation of Childhood CancerThomas R.W. Oliver and Sam BehjatiDevelopmental Modeling of Childhood CancersKosuke Funato and Viviane TabarDevelopmental Heterogeneity of RhabdomyosarcomaBradley T. Stevens and Mark E. HatleyTargeting Hyperactive Ras Signaling in Pediatric CancerAnya Levinson, Kevin Shannon, and Benjamin J. HuangParallels in Canonical Developmental Signaling Pathways between Normal Development and the Tumor MicroenvironmentJuliaSegal, James Cronk, Brendan Ball, Greta Forbes, Kailey Jackett, KathyLi, Alondra Martinez Osorno, Emily San Andres Montalvan, Alice Browne,Jessica Lake, and Rosandra N. KaplanOsteosarcoma through the Lens of Bone Development, Signaling, and MicroenvironmentElizabeth P. Young, Amanda E. Marinoff, Eunice Lopez-Fuentes, and E. Alejandro Sweet-CorderoLineage-Selective Dependencies in Pediatric CancersK. Elaine Ritter and Adam D. DurbinImmunotherapies for Childhood CancerJeong A. Park and Nai-Kong V. CheungAcute Promyelocytic Leukemia, Retinoic Acid, and Arsenic: A Tale of DualitiesDomitille Rérolle, Hsin-Chieh Wu, and Hugues de ThéPrinciples in the Development of Contemporary Treatment of Childhood Malignancies: The First 75 YearsKatie A. Greenzang and Stephen E. SallanCancer Therapies Targeting Cellular MetabolismBenjamin Morris and Alejandro GutierrezAdoptive Cell Therapy for Pediatric Solid TumorsAmy B. Hont and Catherine M. BollardEpigenetic TherapiesWallace Bourgeois, Scott A. Armstrong, and Emily B. HeikampPediatricCancer Drug Development: Leveraging Insights in Cancer Biology and theEvolving Regulatory Landscape to Address Challenges and Guide FurtherProgressRosane Charlab, Ruby Leong, Stacy S. Shord, and Gregory H. ReamanIndex
SynopsisA variety of cancersaffect children and young adults, including leukemias, sarcomas, andtumors of the nervous system. These are caused by errors that occurduring development and arise in specific populations of cells thataccumulate somatic mutations in early life. Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicineprovides a comprehensive review of our understanding of cancers thatoccur during childhood and in young adults, the mechanisms underlyingtheir appearance, and current and future treatment strategies. Recentdiscoveries show these young-onset cancers are fundamentallydevelopmental in origin. The contributors review how developmentalprocesses in the growing body generate cell states that are susceptibleto tumorigenesis in particular types of cells. They discuss the basesfor genetic predisposition, endogenous and exogenous somatic mutationalprocesses, epigenetic regulation, and the influence of the immune andtissue microenvironments. In addition, the authors examine themultiple therapeutic approaches used to target young-onset cancers, suchas combination treatments and immunologic, metabolic, and cellulartherapies. Cancer surveillance is also covered, as well as the uniquechallenges of pediatric cancer drug development. The volume willtherefore be an essential reference for cancer biologists, practicingoncologists, and those interested in how we can drive progress in cancertreatment., A variety of cancers affect children and young adults, including leukemias, sarcomas, and tumors of the nervous system. These are caused by errors that occur during development and arise in specific populations of cells that accumulate somatic mutations in early life. Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine provides a comprehensive review of our understanding of cancers that occur during childhood and in young adults, the mechanisms underlying their appearance, and current and future treatment strategies. Recent discoveries show these young-onset cancers are fundamentally developmental in origin. The contributors review how developmental processes in the growing body generate cell states that are susceptible to tumorigenesis in particular types of cells. They discuss the bases for genetic predisposition, endogenous and exogenous somatic mutational processes, epigenetic regulation, and the influence of the immune and tissue microenvironments. In addition, the authors examine the multiple therapeutic approaches used to target young-onset cancers, such as combination treatments and immunologic, metabolic, and cellular therapies. Cancer surveillance is also covered, as well as the unique challenges of pediatric cancer drug development. The volume will therefore be an essential reference for cancer biologists, practicing oncologists, and those interested in how we can drive progress in cancer treatment.
LC Classification NumberRC263
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