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Advances in Experimental Medicine and Biology Ser.: Gene Therapy for HIV and Chronic Infections by Hildegund C. J. Ertl (2015, Hardcover)
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About this product
Product Identifiers
PublisherSpringer New York
ISBN-101493924311
ISBN-139781493924318
eBay Product ID (ePID)208529711
Product Key Features
Number of PagesXvi, 236 Pages
LanguageEnglish
Publication NameGene Therapy for Hiv and Chronic Infections
SubjectAids & Hiv, Immunology, Genetics, Research, Diseases
Publication Year2015
TypeTextbook
AuthorHildegund C. J. Ertl
Subject AreaMedical
SeriesAdvances in Experimental Medicine and Biology Ser.
FormatHardcover
Dimensions
Item Weight193.5 Oz
Item Length9.3 in
Item Width6.1 in
Additional Product Features
Intended AudienceScholarly & Professional
LCCN2015-932964
Dewey Edition23
Series Volume Number848
Number of Volumes1 vol.
IllustratedYes
Dewey Decimal616.979206
Table Of ContentGene Therapies for Hepatitis C Virus.- Recent Advances in Use of Gene Therapy to Treat Hepatitis B Virus Infection.- U1interference (U1i) for antiviral approaches.- Gene therapy strategies to block HIV-1 replication by RNA interference.- HIV and Ribozymes.- Editing CCR5 : a novel approach to HIV gene therapy.- Synthetic DNA approach to Cytomegalovirus vaccine/immune therapy.- Vector-mediated antibody gene transfer for infectious diseases.- HIV latency and the non-coding RNA therapeutic landscape.- C peptides as entry inhibitors for gene therapy.- Aptamer-siRNA chimeras for HIV
SynopsisThis book centers on gene therapy and gene transfer approaches to prevent or treat chronic virus infections. The main focus is on the Big Three: human immunodeficiency virus (HIV-1), hepatitis B virus (HBV) and hepatitis C virus (HCV). Ample anti-HIV drugs are currently available in the clinic and the development of an effective combination therapy has dramatically improved the lifespan and quality of life of infected individuals. A similar trend can already be recognized for HBV and HCV: the development of multiple (directly acting) antiviral drugs and plans to control or even cure the infection. However, approaches that help prevent infection, or which provide long-lasting treatment (such as a cure) remain important goals. Immunization through gene transfer vehicles encoding immunogenic viral proteins shows promise in preventing infections with complex, highly variable, viruses such as HIV-1 or HCV. Gene therapy applications for virus infections have been discussed since the early 1990's. Whereas a true cure seems difficult to achieve for HIV-1 due to its intrinsic property to deposit its genome into that of the host, such attempts may be within reach for HCV where spontaneous viral clearance occurs in a small percentage of the infected individuals. The prospect of original gene therapy approaches may provide alternative ways to reach the same endpoint by, for example, silencing of CCR5 expression post-transcriptionally. Many alternative antiviral strategies have been developed based on a variety of novel molecular methods: e.g. ribozymes. Some studies have progressed towards pre-clinical animal models and a few antiviral gene therapies have progressed towards clinical trials. This book provides an overview of this rapidly progressing field, while focusing on the interface of gene therapy and immunology/vaccinology.
LC Classification NumberRB155-155.8
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