Picture 1 of 1
Gallery
Picture 1 of 1
Have one to sell?
Methods Molecular Biology: Target Discovery & Validation Reviews & Protocols HC
US $11.00
ApproximatelyRM 46.33
Condition:
Like New
A book in excellent condition. Cover is shiny and undamaged, and the dust jacket is included for hard covers. No missing or damaged pages, no creases or tears, and no underlining/highlighting of text or writing in the margins. May be very minimal identifying marks on the inside cover. Very minimal wear and tear.
Oops! Looks like we're having trouble connecting to our server.
Refresh your browser window to try again.
Pickup:
Free local pickup from Woburn, Massachusetts, United States.
Shipping:
US $4.40 (approx RM 18.53) USPS Media MailTM.
Located in: Woburn, Massachusetts, United States
Delivery:
Estimated between Thu, 21 Aug and Wed, 27 Aug to 94104
Returns:
30 days return. Buyer pays for return shipping. If you use an eBay shipping label, it will be deducted from your refund amount.
Coverage:
Read item description or contact seller for details. See all detailsSee all details on coverage
(Not eligible for eBay purchase protection programmes)
Seller assumes all responsibility for this listing.
eBay item number:335290875485
Item specifics
- Condition
- ISBN
- 9781588296566
About this product
Product Identifiers
Publisher
Humana Press
ISBN-10
1588296563
ISBN-13
9781588296566
eBay Product ID (ePID)
52867513
Product Key Features
Number of Pages
Xii, 354 Pages
Language
English
Publication Name
Target Discovery and Validation Reviews and Protocols Vol. 1 : Emerging Strategies for Targets and Biomarker Discovery
Subject
Life Sciences / Biochemistry, Life Sciences / Genetics & Genomics, Oncology, Pharmacology
Publication Year
2006
Type
Textbook
Subject Area
Science, Medical
Series
Methods in Molecular Biology Ser.
Format
Hardcover
Dimensions
Item Height
0.4 in
Item Weight
27.7 Oz
Item Length
9 in
Item Width
6 in
Additional Product Features
Intended Audience
Scholarly & Professional
LCCN
2006-020032
Reviews
From the reviews:"Volume 1 focuses on novel and innovative techniques, and presents the most up-to-date protocols available for maximizing the likelihood of achieving target-selective inhibition in vivo while minimizing side effects. … Cancer researchers will find tremendous value in the molecular classification of breast cancers and the review of protocols for tumor antigens and cancer vaccines. … provide a thorough review of the most cutting-edge methods available for each step in drug target identification, validation, and clinical application." (Anticancer Research, Vol. 27, May, 2007)"Review current methods for drug target discovery and validation. … Volume 1 is focused on drug target and biomarker discovery. … the chapters are generally well written and clear, and provide extensive references to the current literature. … Overall … provide useful overviews that would provide entry into this field. Novice and more experienced researchers … would find useful information … ." (Jonathan B. Chaires, ChemMedChem, Issue 3, 2008), From the reviews: "Volume 1 focuses on novel and innovative techniques, and presents the most up-to-date protocols available for maximizing the likelihood of achieving target-selective inhibition in vivo while minimizing side effects. ... Cancer researchers will find tremendous value in the molecular classification of breast cancers and the review of protocols for tumor antigens and cancer vaccines. ... provide a thorough review of the most cutting-edge methods available for each step in drug target identification, validation, and clinical application." (Anticancer Research, Vol. 27, May, 2007) "Review current methods for drug target discovery and validation. ... Volume 1 is focused on drug target and biomarker discovery. ... the chapters are generally well written and clear, and provide extensive references to the current literature. ... Overall ... provide useful overviews that would provide entry into this field. Novice and more experienced researchers ... would find useful information ... ." (Jonathan B. Chaires, ChemMedChem, Issue 3, 2008)
Series Volume Number
360
Number of Volumes
1 vol.
Illustrated
Yes
Table Of Content
Main Approaches to Target Discovery and Validation.- Bioinformatics Approaches to Cancer Gene Discovery.- Analysis of Gene Networks for Drug Target Discovery and Validation.- Target Discovery and Validation in Pancreatic Cancer.- Molecular Classification of Breast Tumors.- Discovery of Differentially Expressed Genes.- Genome-Wide Screening by Using Small-Interfering RNA-Expression Libraries.- Hammerhead Ribozyme-Based Target Discovery.- Production of siRNA and cDNA-Transfected Cell Arrays on Noncoated Chambered Coverglass for High-Content Screening Microscopy in Living Cells.- Transgenic Animal Models in Biomedical Research.- Keratin Transgenic and Knockout Mice.- The HUVEC/Matrigel Assay.- A Murine Model for Studying Hematopoiesis and Immunity in Heart Failure.- An Overview of the Immune System and Technical Advances in Tumor Antigen Discovery and Validation.- Potential Target Antigens for Immunotherapy Identified by Serological Expression Cloning (SEREX).- Identification of Tumor Antigens by Using Proteomics.- Protein Arrays.
Synopsis
Target discovery is a field that has existed for several years but is so vibrant today because of the recent progress in our understanding of the molecular mechanisms of many human diseases and the technical advances in target identification and validation. More sophisticated gene profiling technologies, such as DNA microarrays and serial analysis of gene expression, permit rapid identification of lead targets. Moreover, analysis of gene networks in living organisms allows the identification of target genes that operate in defined physiological pathways. With the sequencing of several genomes completed and the rapidly growing gene expression databases, there is now greater impetus than ever before for in silico discovery of therapeutic targets. Also, recent advances in genetic technologies have increased our ability to generate mouse models for human diseases. The implications of these genetically modified animals in drug development are several, including identification of new drug targets, predicting efficacy, and uncovering possible side effects. Together, these recent technical advances should allow researchers to make the most informed choice early and advance the chosen targets toward clinical studies. Regarding cancers, any difference between a cancer and a normal cell could potentially be exploited as a therapeutic target. The hope is that drugs targeting specific constituents or pathways in cancer cells will provide more effective therapy, either alone or in combination with other currently used anticancer drugs. In addition to drug targets, identifying new target antigens remains as much of a challenge as improving tumor vaccines already in the clinic., Target Discovery and Validation: Reviews and Protocols, Volumes 1 and 2 review the most progressive and current methods for drug target discovery and validation. These volumes explore how recent improvement in understanding the molecular mechanisms of human pathology is impacting drug target discovery in the laboratory and in real therapeutics, specifically for cancers and autoimmune disorders. Volume 1 focuses on novel and innovative techniques, and presents the most up-to-date protocols available for maximizing the likelihood of achieving target-selective inhibition in vivo while minimizing side effects. The profound impact of genomics, proteomics and bioinformatics on target discovery is explored, and specific attention is given to the role of transgenic and knockout animals in functional genomics and target validation. Cancer researchers will find tremendous value in the molecular classification of breast cancers and the review of protocols for tumor antigens and cancer vaccines. The methods and protocols collected here, all reviewed by leading scientists and clinicians, present the practical details necessary for translating the enormous discovery potential of the genome into real therapeutic products. Volume 2 collects all the practical details required for efficient translation of discovered targets into real pharmaceutical drugs. Specific targets in cancers and autoimmunity are described and the potential of using siRNA's, antisense oligonucleotides and RNA aptimers in patients is reviewed. This volume explores the tremendous impact of the application of genotyping and gene expression profiling on the future of healthcare, and presents cutting-edge protocols to aid inbringing agents against specific targets closer to application in the clinic. Collectively, these volumes provide a thorough review of the most cutting-edge methods available for each step in drug target identification, validation, and clinical application. For researchers, an understanding of available methods aids in the creation of innovative experiments in the laboratory, and the successful translation of target discovery to real therapeutics.
LC Classification Number
RC254-282
Item description from the seller
Popular categories from this store
Seller feedback (46,138)
- y***f (2158)- Feedback left by buyer.Past monthVerified purchaseGreat Seller!!! Item Received in Excellent Condition!!! Very Highly Recommend!!!
- f***r (4227)- Feedback left by buyer.Past monthVerified purchaseRec book in good order fast shipping and package was perfect Can’t wait to read thanks
- r***o (981)- Feedback left by buyer.Past monthVerified purchaseFast shipping and excellent condition. Thank you!