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The Dose Makes the Poison: A Plain-Language Guide to Toxicology, 3rd Edition
US $8.50
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Condition:
Very Good
A book that has been read but is in excellent condition. No obvious damage to the cover, with the dust jacket included for hard covers. No missing or damaged pages, no creases or tears, and no underlining/highlighting of text or writing in the margins. May be very minimal identifying marks on the inside cover. Very minimal wear and tear.
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Free local pickup from Champaign, Illinois, United States.
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Located in: Champaign, Illinois, United States
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eBay item number:316574335660
Item specifics
- Condition
- ISBN
- 9780470381120
About this product
Product Identifiers
Publisher
Wiley & Sons, Incorporated, John
ISBN-10
0470381124
ISBN-13
9780470381120
eBay Product ID (ePID)
99503145
Product Key Features
Number of Pages
288 Pages
Language
English
Publication Name
Dose Makes the Poison : a Plain-Language Guide to Toxicology
Publication Year
2011
Subject
Toxicology, Public Health, Chemistry / Industrial & Technical
Type
Textbook
Subject Area
Science, Medical
Format
Trade Paperback
Dimensions
Item Height
0.7 in
Item Weight
15.2 Oz
Item Length
9.1 in
Item Width
5.9 in
Additional Product Features
Edition Number
3
Intended Audience
Scholarly & Professional
LCCN
2010-023287
Dewey Edition
22
TitleLeading
The
Reviews
"This is a refreshing, invigorating as well as eye-opening text, which is reading like an exciting novel - even to a seasoned toxicologist ... An appendix to clarify quantities of pollutants plus an index concludes this most valuable introduction into the science of toxicology for a broad readership." (Toxicology, 2011) "I recommend this book to anyone who has ever listened to the evening news and wondered how much of the "chemical scare du jour" is hype and how much of it is fact - and to those who might want to understand basic concepts in toxicology and the related areas of study without having to trudge through a gaggle of 1000-page textbooks." (International Journal of Toxicology, 2011) "Overall, this is a well-written work with wisely chosen and relevant topics. It will be a perfect addition to any science enthusiast's library. Summing Up: Highly recommended. Lower-level undergraduates through professionals/practitioners; general readers." (Choice, 1 September 2011) "The Dose Makes the Poison is more than just an introduction to toxicology. It is an enjoyable read with lots of interesting stories and one I can thoroughly recommend." (Chemistry & Industry, 25 July 2011) "There is much to be applauded in this book from its straightforward layout and honesty to its accessibility . . . Many good, and contemporary, examples are provided to deliver greater context for the reader." (The British Toxicology Society Journal, 1 May 2011)
Illustrated
Yes
Dewey Decimal
615.9
Table Of Content
Introduction to the Third Edition xi Preface to the Second Edition xv 1 What Are Chemicals? 1 Atoms and Molecules 1 Natural Chemicals 2 Synthetic Chemicals 3 Chemical Categories 6 Chemicals: "Good" and "Bad" 8 Why the "Good-Bad" Dichotomy? 10 Man-made Chemicals Are Made by Humans 11 Man-made Chemicals May Not Be Biodegradable 12 Man-made Chemicals May Be Very Complex 16 2 What Harm Do Chemicals Cause? 19 Harmful Properties of Chemicals 19 Explosiveness and Reactivity 19 Flammability and Combustibility 20 Radioactivity 21 Corrosiveness 23 Irritation 23 Sensitization and Photosensitization 24 Toxicity 26 Multiple Harmful Properties 27 Definition of Poison 28 Definition of Hazard 28 3 What Is Toxicology? 31 Empirical Toxicology 31 Paracelsus and Ramazzini 32 A Brief History of Toxicology 34 Toxicology Today 40 What Do Toxicologists Do? 44 4 What Factors Influence the Toxic Effects of Chemicals? 47 Acute versus Chronic Toxicity 47 Significance of Divided Doses 53 Routes of Exposure 54 Dermal Exposure 54 Inhalation Exposure 55 Oral Exposure 58 Other Routes of Exposure 59 Combinations 60 Influence of Route on Toxicity 60 Metabolism 64 Routes of Elimination (Excretion) 65 Other Factors that Influence Toxicity 66 Species 66 Sex 70 Age 71 Nutrition 73 State of Health 73 Biochemical Individuality (Genetic Diversity) 74 Presence of Other Chemicals 75 Adaptation 77 Light 79 5 How Is Toxicology Studied? 81 Experimental Methods 82 Acute Toxicity 83 Irritant and Corrosive Effects 85 Sensitization and Photosensitization 86 Chronic Toxicity 87 Mutagenesis 90 Carcinogenesis 91 Developmental and Reproductive Toxicity 94 Units of Trace Quantities 95 Analytical Methods 96 Animal Rights 99 6 General Toxicology 103 Acute Toxicity 103 LD 50 and LC 50 Values 103 Significance of LDs for Humans 104 Poison Prevention 109 Antidotes 112 Chronic Toxicity 114 No-Effect Levels and Thresholds 116 Margins of Safety 117 Sufficient Challenge 119 Bioaccumulation 121 7 Mutagenesis and Carcinogenesis 129 Mutagenesis 129 Genetic Code 129 Mutations 130 Significance of Mutations 132 Mutation and Cancer 135 Carcinogenesis 138 What Is Cancer? 138 Causes of Cancer 140 Role of Mutation 141 Incidence of Cancer 142 Categories and Characteristics of Carcinogens 143 Induction Periods 146 Thresholds 147 Practical Thresholds 149 The Real World 150 Benzo[a]pyrene 150 Cancerophobia 151 8 Developmental and Reproductive Toxicity 153 Male and Female Reproductive Systems 154 Prepuberty Systems 154 Adult Systems 155 The Developing Individual 156 9 Case Studies in Toxicology 163 Environmental Contaminations 164 Dioxins: Seveso, Italy 164 PCBs and Dibenzofurans: Yusho Disease 169 Bophal, India 173 Minamata Disease 174 Ddt 174 Consumer Products 177 Metals 177 Lead and Cadmium 178 Zinc 178 Plastics 179 Bisphenyl A 180 Indoor Air Pollution 181 Water Pollution 185 Pharmaceuticals 186 Fen-Phen 187 Vioxx 188 Thalidomide 189 10 Epidemiology 191 Origins of Modern Epidemiology 191 Epidemiology of Noninfectious Diseases 193 Koch''s Postulates 195 Study Design: Precepts and Pitfalls 197 Unreasonable Expectations 201 Proximate Event Approach in Assigning Cause 202 Distrust of Science and Scientists 204 11 the Study of Risk 211 Public Health Statistics 211 Inherent Risk 213 Risk Assessment 215 Perceived Risk 218 Acceptable Risk 220 Risk Benefit and Cost Benefit 222 Risk Communication 225 Risk Management 227 Bibliography 229 Abbreviations 233 Glossary 235 Appendix A 245 Index 247
Synopsis
This new edition of a widely-read and highly-acclaimed book broadens the scope of its predecessors from a heavy focus on industrial chemicals as toxicants to include drugs, food additives, cosmetics and other types of compounds that people are exposed to daily. Also new to the 3rd edition are newer issues-of-the-day such as nanoparticulate toxicants, second hand smoke, food contamination, lead in toys, and others. As such, the book provides the basics of toxicology in easy-to-understand language as well as a fuller understanding of the daily insults to which our bodies are subjected., An introductory guide to the history, concepts, and practice of toxicology With the advent of serious industrialization in non-Western economies such as China and India, the integrity of our food supply is once again in question and the safety of various consumer products and medicines at risk. Every day, people are exposed to a wide array of chemicals and other potential toxicants--from industrial emissions, the natural environment, drugs, and consumer products. Using broadly accessible language and clear examples, the Third Edition of The Dose Makes the Poison updates its highly acclaimed predecessors and explains the basics and practice of toxicology in easy-to-understand language. This new edition broadens its scope from a heavy focus on industrial chemicals as toxicants to include drugs, food additives, cosmetics, and other types of compounds that people are exposed to daily. Also new to the Third Edition are recent issues-of-the-day such as bisphenol A, secondhand smoke, food contamination, lead in toys, melamine toxicity to children and pets, and drug recalls. Basic principles of how doses and routes of administration alter toxicity, testing paradigms for drugs and chemicals, and newer technology such as nanoparticles are all addressed and explained. In addition, the book: Presents case studies of historical and current interest to illustrate various aspects of toxicology Deals with all types of chemicals that we confront every day, including drugs, food additives, vitamins, and others Includes an introduction to how chemicals cause harm, the factors that influence toxicity, and the ways that chemicals and drugs are tested to determine their safety, The toxicity of a chemical depends on the dose--the amount of exposure to the substance. The Dose Makes the Poison, Third Edition broadens the scope of its predecessors from a heavy focus on industrial chemicals as toxicants to include drugs, food additives, cosmetics, and other compounds that people are exposed to daily.
LC Classification Number
RA1213.O88 2011
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Seller feedback (6,844)
- t***2 (314)- Feedback left by buyer.Past monthVerified purchaseGreat communication, Thank you
- 9***d (786)- Feedback left by buyer.Past monthVerified purchaseGood
- 4***n (490)- Feedback left by buyer.Past monthVerified purchasegreat!